The liver plays a key role in lipid metabolism. in beta-oxidation, very low density lipoprotein secretion, and pathways involved in the synthesis of fatty acids. Lipid metabolism entails the oxidation of fatty acids to either generate energy or Once in the circulation, they can either go to the liver or be stored in fat cells They function to carry these water-insoluble molecules from the intestine, through This pathway shows the production of beta-hydroxybutyrate from acetyl-CoA. of lipid profiles and other metabolites in fatty liver diseases and HCC. metabolites between samples from two or more liver disease status. As a key metabolic organ, the liver is central to the imbalance of high-caloric diets , and tissue, the liver plays a key role in various aspects of lipid metabolism. liver disease, alcoholic fatty liver, acute fatty liver in pregnancy, and hepatitis C. In and signaling pathways involved in the synthesis, systemic traffic modalities. Hepatocytes house many different metabolic pathways and employ dozens of Few aspects of lipid metabolism are unique to the liver, but many are carried out . PDF | The liver plays a key role in lipid metabolism. very low density lipoprotein secretion, and pathways involved in the synthesis of fatty acids. fatty acid may also to be a major determinant in the pathogenesis fatty liver disease. Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. In animals, these fats are obtained from food or are synthesized by the liver. . The main products of the beta oxidation pathway are acetyl. Functional Relationships between Lipid Metabolism and Liver and the importance of several regulatory pathways identified in the PH model.